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DIVISION OF MOLECULAR EPIDEMIOLOGY AND POPULATION GENETICS


About


The main goal of the section is to conduct research in the field of Molecular Epidemiology and Population Genetics. The main thrust is on accurate measurement of exposures and investigates life style, environmental and genetic risk factors for common cancer sites in India by using case control and longitudinal cohort study designs.

Objective


  • Established Cancer Epidemiology and Genetic network to undertake multicentric studies to identify lifestyle. Environmental and genetic risk factors of common cancer.
  • Expanded longitudinal Cohort studies in Barshi to other centers (Varanasi, Guwahati, Sangrror and Mullanpur).
  • Develop and established workflow and pipeline for large scale GWAS studies.
  • Developed and established workflow and pipeline for Shotgun Mutagenomic studies.• Developed and established workflow for Whole genome and targeted sequencing.

Research and Activities

Training


UPCOMING !!

Publications


PMID: 25220842

Title: Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012

Authors: Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F.

Citation: Int J Cancer. 2015 Mar 1;136(5):E359-86. doi: 10.1002/ijc.29210. Epub 2014 Oct 9.

First Author: Ferlay J

Publication Year: 2015

DOI: 10.1002/ijc.29210

Url : View Link

PMID: 35510141

Title: Prevalence of human papillomavirus types in head and neck cancer sub-sites in the Indian population

Authors: Gholap D, Mhatre S, Chaturvedi P, Nair S, Gheit T, Tommasino M, Dikshit R.

Citation: Ecancermedicalscience. 2022 Feb 18;16:1358. doi: 10.3332/ecancer.2022.1358. eCollection 2022.

First Author: Gholap D

Publication Year: 2022

DOI: 10.3332/ecancer.2022.1358

Url : View Link

PMID: 32773421

Title: Geographical & seasonal variation in COVID-19 related mortality

Authors: Badwe RA, Dikshit R, Chaturvedi P, Gupta S.

Citation: Indian J Med Res. 2020 Jul & Aug;152(1 & 2):6-8. doi: 10.4103/ijmr.IJMR_2043_20.

First Author: Badwe RA

Publication Year: 2020

DOI: 10.4103/ijmr.IJMR_2043_20

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PMID: 34550362

Title: Reproductive factors and gall-bladder cancer, and the effect of common genetic variants on these associations: a case-control study in India.

Authors: Mhatre S, Lacey B, Sherliker P, Chatterjee N, Rajaraman P, Goel M, Patkar S, Ostwal V, Patil P, Shrikhande SV, Chitkara G, Badwe R, Lewington S, Dikshit R.

Citation: Int J Epidemiol. 2022 Jun 13;51(3):789-798. doi: 10.1093/ije/dyab197.

First Author: Mhatre S

Publication Year: 2022

DOI: 10.1093/ije/dyab197

Url : View Link

PMID: 36418768

Title: Epidemiological Trend of Esophageal Cancer at a Tertiary Cancer Center in Mumbai, India, Over the Past 15 Years.

Authors: Noronha V, Sekar A, Rajendra A, Mokal S, Patil V, Menon N, Chopade S, Singh AK, Kaushal RK, Mahajan A, Janu A, Purandare N, Dikshit R, Banavali S, Prabhash K, Badwe R.

Citation: J Gastrointest Cancer. 2022 Nov 23. doi: 10.1007/s12029-022-00887-z. Online ahead of print.

First Author: Noronha V

Publication Year: 2022

DOI: 10.1007/s12029-022-00887-z

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PMID: 33187967

Title: The Role of Gallstones in Gallbladder Cancer in India: A Mendelian Randomization Study

Authors: Mhatre S, Richmond RC, Chatterjee N, Rajaraman P, Wang Z, Zhang H, Badwe R, Goel M, Patkar S, Shrikhande SV, Patil PS, Davey Smith G, Relton CL, Dikshit RP.

Citation: Cancer Epidemiol Biomarkers Prev. 2021 Feb;30(2):396-403. doi: 10.1158/1055-9965.EPI-20-0919. Epub 2020 Nov 13.

First Author: Mhatre S

Publication Year: 2021

DOI: 10.1158/1055-9965.EPI-20-0919

Url : View Link

PMID: 32436873

Title: Utility of dried blood spots in detecting helicobacter pylori infection

Authors: Kumar A, Mhatre S, Dikshit R.

Citation: Indian J Med Microbiol. 2019 Oct-Dec;37(4):514-520. doi: 10.4103/ijmm.IJMM_19_441..

First Author: Kumar A

Publication Year: 2019

DOI: 10.4103/ijmm.IJMM_19_441

Url : View Link

PMID: 33958335

Title: Clinical course and outcome of patients with COVID-19 in Mumbai City: an observational study

Authors: de Souza R, Mhatre S, Qayyumi B, Chitkara G, Madke T, Joshi M, Bharmal R, Asgaonkar DS, Lakhani P, Gupta S, Chaturvedi P, Dikshit R, Badwe R.

Citation: BMJ Open. 2021 May 6;11(5):e042943. doi: 10.1136/bmjopen-2020-042943.

First Author: de Souza R

Publication Year: 2021

DOI: 10.1136/bmjopen-2020-042943

Url : View Link

PMID: 27198840

Title: Level of evidence of verbal autopsy - Authors' reply

Authors: Ram U, Dikshit R, Jha P.

Citation: Lancet Glob Health. 2016 Jun;4(6):e368-9. doi: 10.1016/S2214-109X(16)30045-6.

First Author: Ram U

Publication Year: 2016

DOI: 10.1016/S2214-109X(16)30045-6

Url : View Link

PMID: 26855528

Title: Institutional external peer review: A unique National Cancer Grid initiative

Authors: Raghunadharao D, Kannan R, Hingnekar C, Vijaykumar DK, Mani CS, Ghosh-Laskar S, Gujral S, Chaudhari S, Nayak S, Dikshit R, Badwe RA, Pramesh CS; National Cancer Grid.

Citation: Indian J Med Paediatr Oncol. 2015 Jul-Sep;36(3):186-8. doi: 10.4103/0971-5851.166753.

First Author: Raghunadharao D

Publication Year: 2015

DOI: 10.4103/0971-5851.166753

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PMID: 24889780

Title: HPV-avertable cancer risks in India: a pooled analysis of 9 observational studies

Authors: Patra J, Dikshit R, Bhatia M, Ramasundarahettige C, Jha P.

Citation: Int J Cancer. 2015 Jan 15;136(2):491-2. doi: 10.1002/ijc.28998. Epub 2014 Jun 11.

First Author: Patra J

Publication Year: 2015

DOI: 10.1002/ijc.28998

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PMID: 26589416

Title: Understanding rural-urban differences in risk factors for breast cancer in an Indian population

Authors: Nagrani R, Mhatre S, Boffetta P, Rajaraman P, Badwe R, Gupta S, Romieu I, Parmar V, Dikshit R.

Citation: Cancer Causes Control. 2016 Feb;27(2):199-208. doi: 10.1007/s10552-015-0697-y. Epub 2015 Nov 20.

First Author: Nagrani R

Publication Year: 2016

DOI: 10.1007/s10552-015-0697-y

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PMID: 32142159

Title: Mustard oil consumption, cooking method, diet and gallbladder cancer risk in high- and low-risk regions of India

Authors: Mhatre S, Rajaraman P, Chatterjee N, Bray F, Goel M, Patkar S, Ostwal V, Patil P, Manjrekar A, Shrikhande SV, Badwe R, Dikshit R.

Citation: Int J Cancer. 2020 Sep 15;147(6):1621-1628. doi: 10.1002/ijc.32952. Epub 2020 Mar 30.

First Author: Mhatre S

Publication Year: 2020

DOI: 10.1002/ijc.32952

Url : View Link

PMID: 28098224

Title: Association of Genome-Wide Association Study (GWAS) Identified SNPs and Risk of Breast Cancer in an Indian Population

Authors: Nagrani R, Mhatre S, Rajaraman P, Chatterjee N, Akbari MR, Boffetta P, Brennan P, Badwe R, Gupta S, Dikshit R.

Citation: Sci Rep. 2017 Jan 18;7:40963. doi: 10.1038/srep40963.

First Author: Nagrani R

Publication Year: 2017

DOI: 10.1038/srep40963

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PMID: 31242925

Title: Automated versus physician assignment of cause of death for verbal autopsies: randomized trial of 9374 deaths in 117 villages in India

Authors: Jha P, Kumar D, Dikshit R, Budukh A, Begum R, Sati P, Kolpak P, Wen R, Raithatha SJ, Shah U, Li ZR, Aleksandrowicz L, Shah P, Piyasena K, McCormick TH, Gelband H, Clark SJ.

Citation: BMC Med. 2019 Jun 27;17(1):116. doi: 10.1186/s12916-019-1353-2.

First Author: Jha P

Publication Year: 2019

DOI: 10.1186/s12916-019-1353-2

Url : View Link

PMID: 27726981

Title: Economic evaluation of Mumbai and its satellite cancer registries: Implications for expansion of data collection

Authors: Koyande S, Subramanian S, Edwards P, Hoover S, Deshmane V, Tankga F, Dikshit R, Saraiya M.

Citation: Cancer Epidemiol. 2016 Dec;45 Suppl 1(Suppl 1):S43-S49. doi: 10.1016/j.canep.2016.10.002. Epub 2016 Oct 7.

First Author: Koyande S

Publication Year: 2016

DOI: 10.1016/j.canep.2016.10.002

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PMID: 31815249

Title: Optimization of extraction of genomic DNA from archived dried blood spot (DBS): potential application in epidemiological research & bio banking

Authors: Kumar A, Mhatre S, Godbole S, Jha P, Dikshit R.

Citation: Gates Open Res. 2019 Nov 14;2:57. doi: 10.12688/gatesopenres.12855.3. eCollection 2018.

First Author: Kumar A

Publication Year: 2019

DOI: 10.12688/gatesopenres.12855.3

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PMID: 30012272

Title: Divergent trends in ischaemic heart disease and stroke mortality in India from 2000 to 2015: a nationally representative mortality study

Authors: Ke C, Gupta R, Xavier D, Prabhakaran D, Mathur P, Kalkonde YV, Kolpak P, Suraweera W, Jha P; Million Death Study Collaborators.

Citation: Lancet Glob Health. 2018 Aug;6(8):e914-e923. doi: 10.1016/S2214-109X(18)30242-0.

First Author: Ke C

Publication Year: 2018

DOI: 10.1016/S2214-109X(18)30242-0

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PMID: 28588906

Title: Trends in bidi and cigarette smoking in India from 1998 to 2015, by age, gender and education

Authors: Mishra S, Joseph RA, Gupta PC, Pezzack B, Ram F, Sinha DN, Dikshit R, Patra J, Jha P.

Citation: BMJ Glob Health. 2016 Apr 6;1(1):e000005. doi: 10.1136/bmjgh-2015-000005. eCollection 2016.

First Author: Mishra S

Publication Year: 2016

DOI: 10.1136/bmjgh-2015-000005

Url : View Link

PMID: 28274756

Title: Common genetic variation and risk of gallbladder cancer in India: a case-control genome-wide association study

Authors: Mhatre S, Wang Z, Nagrani R, Badwe R, Chiplunkar S, Mittal B, Yadav S, Zhang H, Chung CC, Patil P, Chanock S, Dikshit R, Chatterjee N, Rajaraman P.

Citation: Lancet Oncol. 2017 Apr;18(4):535-544. doi: 10.1016/S1470-2045(17)30167-5. Epub 2017 Mar 5.

First Author: Mhatre S

Publication Year: 2017

DOI: 10.1016/S1470-2045(17)30167-5

Url : View Link

PMID: 26683034

Title: Primary liver cancer deaths and related years of life lost attributable to hepatitis B and C viruses in India

Authors: Islami F, Dikshit R, Mallath MK, Jemal A.

Citation: Cancer Epidemiol. 2016 Feb;40:79-86. doi: 10.1016/j.canep.2015.11.012. Epub 2015 Dec 9.

First Author: Islami F

Publication Year: 2016

DOI: 10.1016/j.canep.2015.11.012

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PMID: 26566748

Title: Age-specific and sex-specific adult mortality risk in India in 2014: analysis of 0·27 million nationally surveyed deaths and demographic estimates from 597 districts

Authors: Ram U, Jha P, Gerland P, Hum RJ, Rodriguez P, Suraweera W, Kumar K, Kumar R, Dikshit R, Xavier D, Gupta R, Gupta PC, Ram F. .

Citation: Lancet Glob Health. 2015 Dec;3(12):e767-75. doi: 10.1016/S2214-109X(15)00091-1.

First Author: Ram U

Publication Year: 2015

DOI: 10.1016/S2214-109X(15)00091-1

Url : View Link

PMID: 36054453

Title: Exclusive use of different types of tobacco products, exposure to secondhand tobacco smoke and risk of subtypes of head and neck cancer among Indian males

Authors: Gholap D, Dikshit R, Chaturvedi P, Chaturvedi AK, Manjrekar A, Mhatre S.

Citation: Int J Cancer. 2023 Feb 1;152(3):374-383. doi: 10.1002/ijc.34258. Epub 2022 Sep 8.

First Author: Gholap D

Publication Year: 2023

DOI: 10.1002/ijc.34258

Url : View Link

PMID: 30219626

Title: The burden of cancers and their variations across the states of India: the Global Burden of Disease Study 1990-2016

Authors: India State-Level Disease Burden Initiative Cancer Collaborators.

Citation: Lancet Oncol. 2018 Oct;19(10):1289-1306. doi: 10.1016/S1470-2045(18)30447-9. Epub 2018 Sep 12.

First Author: India State-Level Disease Burden Initiative Cancer Collaborators

Publication Year: 2018

DOI: 10.1016/S1470-2045(18)30447-9

Url : View Link

PMID: 36603919

Title: Cancer survival in Africa, central and south America, and Asia (SURVCAN-3): a population-based benchmarking study in 32 countries

Authors: Soerjomataram I, Cabasag C, Bardot A, Fidler-Benaoudia MM, Miranda-Filho A, Ferlay J, Parkin DM, Ranganathan R, Piñeros M, Znaor A, Mery L, Joko-Fru YW, Dikshit R, Sankaranarayanan R, Swaminathan R, Bray F; SURVCAN-3 collaborators.

Citation: Lancet Oncol. 2023 Jan;24(1):22-32. doi: 10.1016/S1470-2045(22)00704-5.

First Author: Soerjomataram I

Publication Year: 2023

DOI: 10.1016/S1470-2045(22)00704-5

Url : View Link

PMID: 32346024

Title: Common genetic variation in obesity, lipid transfer genes and risk of Metabolic Syndrome: Results from IDEFICS/I.Family study and meta-analysis

Authors: Nagrani R, Foraita R, Gianfagna F, Iacoviello L, Marild S, Michels N, Molnár D, Moreno L, Russo P, Veidebaum T, Ahrens W, Marron M.

Citation: Sci Rep. 2020 Apr 28;10(1):7189. doi: 10.1038/s41598-020-64031-2.

First Author: Nagrani R

Publication Year: 2020

DOI: 10.1038/s41598-020-64031-2

Url : View Link

PMID: -

Title: Trends in Gallbladder Cancer Incidence in the High? and Low?Risk Regions of India"Prachi Ravindra Phadke

Authors: Sharayu Sitaram Mhatre

Citation: Atul Madhukar Budukh

First Author: Rajesh Prabhakar Dikshit" Prachi Ravindra Phadke Indian Journal of Medical and Paediatric Oncology 2021

Publication Year:

DOI:

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PMID: 27573429

Title: Central obesity increases risk of breast cancer irrespective of menopausal and hormonal receptor status in women of South Asian Ethnicity "Nagrani R

Authors: Nagrani R, Mhatre S, Rajaraman P, Soerjomataram I, Boffetta P, Gupta S, Parmar V, Badwe R.

Citation: Dikshit R." Eur J Cancer. 2016 Oct;66:153-61. doi: 10.1016/j.ejca.2016.07.022. Epub 2016 Aug 27. Nagrani R Eur J Cancer 2016 31/08/2016 PMC5040194 10.1016/j.ejca.2016

First Author:

Publication Year: 2016

DOI: 10.1016/j.ejca.2016.07.022

Url : View Link

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Personnel


Dr. Rajesh Dikshit

DIRECTOR CCE

Dr. Rajesh Dikshit

Scientific Officer 'H'

Mr. Pravin Doibale

STAFF

Mr. Pravin Doibale

Scientific Officer 'C'

Mrs. Ankita Manjrekar

STAFF

Ms. Ankita Manjrekar

Data Manager

Mrs. Lekha Kotkar

STAFF

Mrs. Lekha Kotkar

Data Manager

Mr. Nilesh Gawas

STAFF

Mr. Nilesh Gawas

Scientific Assistant 'B'